A pair of Clemson scientists has receiveda collaborative $1.
8 million grant from the National Institutes of Health to study proteindefects in the pancreas that might one day lead to novel therapeutic treatments for Type2 diabetes.
We use computer modeling to understand themechanism and then we make predictions.
And those predictions have to be validated.
Because computer simulation people, not everybodyin the field believes, okay, you’ve got this.
So a prediction is a prediction.
You have to validate it.
So that’s where my collaborators come into play the role.
First they will validate it.
And once they validate it, then we’ll havea synergetic understanding of the mechanism.
Then we can move further to design therapeuticapproaches based on what we’ve learned.
Without knowing the mechanism, you don’tknow how to do the next step.
You can blindly test something and it couldwork.
Without knowing the mechanism, you don’tknow how to improve it.
So the whole thing might not necessarily leadimmediately to a drug, but that’s the overall goal, that’s what we’re building on.
So once we have a better understanding ofthe mechanisms, we’ll have a better assessment of the effectiveness of the small compoundsand nanoparticles that will bring us closer to the overall goal.